Tianyi Mao

Research Interests

My laboratory is interested in elucidating the circuit mechanisms governing the motor control in healthy and disease brains. Specifically, we use advance imaging techniques in combination with modern anatomical, genetic and functional circuitry analysis tools in mouse model to examine the principles governing neuronal connectivity among the cortex, thalamus and basal ganglia, which are involved in motor control and sensory-motor integration. We current focus on two parallel circuitry organization principles in the cortex and the striatum because alterations to these two circuits are the pivotal part of perturbations in the degenerative diseases, such as Alzheimer’s disease and frontotemporal dementia.