Research Interests
Exploring the mechanism of tumorigenesis in Pancreatic Adenocarcinoma (PDAC). Developing new therapy for PDAC specifically targeting the metabolic vulnerability.
Research Interests
Responding to the surrounding environment is one of the vital traits of a living organism. In particular sensing light is a most important perception and way of gathering information for most species. Our lab is hence interested in understanding physiological characteristics and signaling mechanisms of photo-sensation, revealing neural circuits involved in this process and exploring possibilities for vision repair.
Research Interests
How do we learn new skills, and how do we store memories? Since Richard Semon brought us the term of ‘memory engram’ about a century ago, numerous animal and computational models, behavioral paradigms, and experimental techniques have been developed to trace the memory formation and storage in the brain. Accumulating evidence has suggested that behavioral learning may induce specific changes in neuronal excitability, activity and/or connectivity in certain brain regions and neuronal populations, which could serve as a potential locus for memory engram. However, a comprehensive unit encoding sufficient and causal information for memory engram and the mechanisms underlying it remains absolutely elusive.
In my laboratory, we use rodent models to explore the neural pathways, neuronal ensembles, and synaptic activity/plasticity that underlying memory formation and storage/retrieval mechanisms. Rodent behavior training, in vivo tetrode recording, in vivo imaging, slice recording, optogenetics and immunohistochemistry are used in these studies.
https://medicine.stonybrookmedicine.edu/neurobiology/faculty/Xiong
Awards and Honors
Mid-Atlantic Regional Zebrafish Meeting, Best Poster Award (Nov 2014)
Publications
- Delaspre F, Beer RL, Rovira M, Huang W, Wang G, Gee S, Vitery MD, Wheelan SJ, Parsons MJ. Centroacinar cells are progenitors that contribute to endocrine pancreas regeneration. Diabetes. 2015.
- Huang W, Wang G, Delaspre F, Vitery Mdel C, Beer RL, Parsons MJ. Retinoic acid plays an evolutionarily conserved and biphasic role in pancreas development. Dev Biol. 2014;394(1):83-93
- Marika Miot, Michael Reidy, Shannon M. Doyle, Joel R. Hoskins, Danielle Johnston, Olivier Genest, Maria-Carmen Vitery, Daniel C. Masison and Sue Wickner. Species-specific collaboration of heat shock proteins (Hsp) 70 and 100 in thermotolerance and protein disaggregation. Proc Natl Acad Sci USA. 2011;108(17):6915-20.