The Wolfgang laboratory studies the role and regulation of cellular and organismal metabolism. The research in the Wolfgang laboratory utilizes biochemistry and molecular genetics to understand the molecular mechanisms used to sense and respond to nutritional/metabolic cues. We are particularly interested in deciphering the roles of unexplored metabolic enzymes/pathways and determining novel roles of cannonical metabolic pathways in under-explored cells and tissues.
Translational impairment in neurodegenerative diseases.
2022-Present Muscular Dystrophy Association Scholar
2021-2022 Toffler Scholar Award
2019-2021 Milton Safenowitz Postdoctoral Fellowship, ALS Association
2012 – China National Scholarship
My research focus on the production and degradation of the dipeptide repeat proteins (DPRs) in C9ORF72-ALS/FTD, whose accumulation is known to be toxic to neurons. I am particularly interested in investigating the modifiers of these processes by different screening approaches in neurons. This understanding will provide important insight on potential biomarker and therapeutic strategy development.
2024 – Paul Ehrlich Research Award, JHMI
2021 – 3rd place in basic science at National Kidney Foundation Young Investigators
Forum 2021, USA
2016 – Hong Kong special administrative region government scholarship, Hong Kong
2014 – Graduate scholarship, Jinan University, Guangzhou, China
2013 – Award in graduate medicine BBS, Jinan University, Guangzhou, China
2008 – National Motivational Scholarships, Hengyang Normal University, Hengyang, China
Uncovering the physiological role of GPCRs in the kidney