My project centers on the chaperone-like function of the Secretory Pathway Ca2+ATPase isoform 2 (SPCA2) in trafficking Orai1 to the plasma membrane and in deciphering a functional link with E-cadherin, a cell-adhesion molecule. I am also interested in the role of SPCA2 and Ca2+ signaling during the epithelial-mesenchymal transition (EMT) in breast cancer. The regulation of intracellular Ca2+ may offer therapeutic potential in controlling tumor growth and metastasis.
Dang D, Rao R. Calcium-ATPases: Gene disorders and dysregulation in cancer. Biochim Biophys Acta. 2015 Nov 30. doi: 10.1016/j.bbamcr.2015.11.016