Victoria Halperin Kuhns

Awards and Honors

NRSA Fellowship (2015-2018)

APS Abstract-based Travel Awards (meritorious) for Postdoctoral Fellows, Graduate, and Undergraduate Students [2015 APS Conference: Cardiovascular, Renal, and Metabolic Diseases: Physiology and Gender] Halperin Kuhns, VL and Pluznick, JL. “Sex Differences in Renal Gene Expression in a Diet Induced Obesity Model of Diabetic Nephropathy(DN)”

Research Interests

I am currently working in laboratory of Owen Woodward in the Department of Physiology, focusing on renal physiology and epithelial transport. We are studying molecular mechanisms of uric acid homeostasis and how that related to health and disease (including inflammatory arthritis/gout, kidney disease, metabolic disorders, cardiovascular disease and hypertension.) My current focus is on the urate transporter protein, ABCG2, and what regulates its transcription, post-translational modifications, and overall function using a variety of in vitro and in vivo techniques, including classifying a novel mouse model we have developed.

Publications

1. Gabelli SB, Boto A, Kuhns VH, Bianchet MA, Farinelli F, Aripirala S, Yoder J, Jakoncic J, Tomaselli GF, Amzel LM. Regulation of the NaV1.5 cytoplasmic domain by calmodulin. Nat Commun. 2014 Nov 5;5:5126. doi: 10.1038/ncomms6126
2. Agnetti G, Halperin VL, Kirk JA, Chakir K, Guo Y, Lund L, Nicolini F, Gherli T, Guarnieri C, Caldarera CM, Tomaselli GF, Kass DA, Van Eyk JE. Desmin modifications associate with amyloid-like oligomers deposition in heart failure. Cardiovasc Res. 2014 Apr 1;102(1):24-34.