G. William Wong

Our lab seeks to understand mechanisms employed by cells and tissues to maintain metabolic homeostasis. We are broadly interested in how secreted hormones control various aspects of sugar and fat metabolism. Our current efforts centered on addressing how fat and muscle-derived secretory proteins (adipokines and myokines), identified in our lab, regulate tissue crosstalk and signaling pathways to control energy metabolism. We use genetic approaches (gain and loss-of-function mouse models), and cell model systems, to address the function of CTRP family of hormones in physiological and pathophysiological context.