Mechanisms of neurodegeneration and regeneration.

Genetic and molecular mechanisms of the response to stress.

Identification and regulation of small intestinal NaCl absorbing transport proteins.

Mechanisms of carotid body chemotransduction; reflex mechanisms involved in cardiopulmonary control.

Mammalian developmental genetics.

My research investigates the physiology and pathology of ion channels in non-excitable cells.

Secretory and membrane protein sorting in polarized cells.

Physiological function & macromolecular organization of signaling molecules that mediate neuronal excitability & plasticity. Structure, function, biogenesis of potassium channels, and human diseases caused by defective ion channel proteins.

Structure-function relationship of ion-channels; metabolic control of ion homeostasis; cardiac excitation-contraction coupling.

Biochemistry and chemistry of lipids and lipid metabolizing enzymes involved in signaling cascades

Systems analysis of the circulation.

Medical education, pulmonary circulation and hypoxia, respiratory muscle function in neuromuscular diseases.

Role of the cystic fibrosis transmembrane conductance regulator in lung development; neonatal gene therapy for cystic fibrosis using adeno-associated virus, pharmacological therapy for cystic fibrosis.