|Current Position||Assistant Professor|
|Location||Stony Brook University|
|Education||B.S. in Biology, University of Science and Technology of China|
Dr. Min Li
How do we learn new skills, and how do we store memories? Since Richard Semon brought us the term of ‘memory engram’ about a century ago, numerous animal and computational models, behavioral paradigms, and experimental techniques have been developed to trace the memory formation and storage in the brain. Accumulating evidence has suggested that behavioral learning may induce specific changes in neuronal excitability, activity and/or connectivity in certain brain regions and neuronal populations, which could serve as a potential locus for memory engram. However, a comprehensive unit encoding sufficient and causal information for memory engram and the mechanisms underlying it remains absolutely elusive.
In my laboratory, we use rodent models to explore the neural pathways, neuronal ensembles, and synaptic activity/plasticity that underlying memory formation and storage/retrieval mechanisms. Rodent behavior training, in vivo tetrode recording, in vivo imaging, slice recording, optogenetics and immunohistochemistry are used in these studies.