Guang William Wong
|Link to Lab Homepage|
Center for Metabolism and Obesity Research
|Mailing Address||855 N. Wolfe Street|
Baltimore, MD 21205
Mechanisms governing metabolic homeostasis; function of adipose-and skeletal muscle-derived hormones; mechanisms of insulin resistance and type 2 Diabetes
Our lab seeks to understand mechanisms employ by cells and tissues to maintain metabolic homeostasis. We are currently addressing how adipose- and skeletal muscle-derived hormones (adipokines and myokines), discovered in our lab, regulate tissue crosstalk and signaling pathways to control energy metabolism. Transgenic and knockout mouse models, as well as cell culture systems, are used to address the role of CTRP family of hormones in physiological and disease states. We also aim to identify the receptors that mediate the biological functions of CTRPs.
X, Li Q, Rodriguez S, Tan SY, Seldin MM, McLenithan JC, Jia W, Wong GW.
(2015) Thromboxane synthase deficiency improves insulin action and attenuates
adipose tissue fibrosis. Am J Physiol Endocrinol Metab. 308: E792-804
X, Clister TL, Lowry PR, Seldin MM, Wong GW, Zhang J (2015)
Dynamic visualization of the mechanistic target of rapamycin complex 1 (mTORC1)
activity in living cells. Cell Rep. 10:1-11
Multhaup ML, Seldin MM, Jaffe AE, Lei X, Kirchner H, Mondal P, Li
Y, Rodriguez V, Drong A, Hussain M, Lindgren C, McCarthy M, Naslund E, Zierath
J, Wong GW, Feinberg AP. (2015) Mouse-human
experimental epigenetic analysis unmasks dietary targets and genetic liability
for diabetic phenotypes. Cell Metab. 21:138-149
PubMed ReferencePetersen PS, Lei X, Seldin MM, Rodriguez S, Byerly MS, Wolfe A,
Whitlock S, Wong GW. (2014) Dynamic and extensive metabolic
state-dependent regulation of cytokine expression and circulating levels. Am
J Physiol Regul Integr Comp Physiol. 307:R1458-1470
Seldin MM, Byerly MS, Petersen
PS, Swanson R, Balkema-Buschmann A, Groschup M, Wong GW. (2014) Seasonal
oscillation of liver-derived hibernation protein (HP) complex in the central
nervous system of non-hibernating mammals. J. Exp. Biol. 217:2667-2679
Wei Z, Lei X, Pedersen PS, Aja S, and Wong GW. (2014) Targeted deletion of CTRP9 increases food intake, decreases insulin sensitivity, and promotes hepatic steatosis in mice. Am J Physiol Endocrinol Metab. 306:E779-E790
Am Journal of Physiology
Peterson JM, Seldin M,Tan SY, and Wong GW. (2014) CTRP2 overexpression improves insulin and lipid tolerance in diet-induced obese mice. PLoS One 9(2):e88535
Byerly MS, Petersen PS, Ramamurthy S, Seldin MM, Lei X, Provost E, Wei Z, Ronnett GV, and Wong GW. (2014) CTRP4 is a unique secreted protein with two tandem C1q domain that functions in the hypothalamus to modulate food intake and body weight. J Biol Chem. 289:
Journal of Biological Chemistry
Seldin MM, Lei X, Tan S, Stanson KP, Wei Z, and Wong GW. (2013) Skeletal muscle-derived myonectin activates the mTOR pathway to suppress autophagy in liver. J Biol Chem. 288:36073-82
Journal of Biological Chemistry
Byerly MS, Swanson R, Wong GW, and Blackshaw S. (2013) Stage-specific inhibition of TrkB leads to long-lasting and sexually dimorphic effects on body weight and hypothalamic gene expression. PLoS One 8(11):e80781
Peterson JM, Wei Z, Seldin MM, Byerly MS, Aja S, and Wong GW. (2013) CTRP9 transgenic mice are protected from diet-induced obesity and metabolic dysfunctions. Am J Physiol Regul Integr Comp Physiol. Am J Physiol. 305:R522-533
Peterson JM, Seldin MM, Wei Z, Aja S, and Wong GW. (2013) CTRP3 attenuates diet-induced hepatic steatosis by regulating triglyceride metabolism. Am J Physiol Gastrointest Liver Physiol. 305:G214-224
Byerly MS, Swanson R, Kwon K, Aja S, Moran TH, Wong GW, and Blackshaw S. (2013) Hypothalamic Neuron-derived Neurotrophic Factor (NENF) interacts with BDNF and melanocortin signaling to modulate food intake. Am J Physiol Regul Integr Comp Physiol. 304:R1085-R1095
Am Journal of Physiology
Byerly MS, Swanson R, Wei Z, Seldin MM, McCulloh PS, and Wong GW. (2013) A central role for C1q/TNF-related protein-13 (CTRP13) in modulating food intake and body weight. PLoS One 8(4): e62862
llis JM, Wong GW, Wolfgang MJ. (2013) Acyl-CoA Thioesterase 7 regulates neuronal fatty acid metabolism to prevent neurotoxicity. Mol. Cell Biol. 33:1869-1882
Wei Z, Seldin MM, Natarajan N, DjemalDC, Peterson JM, and Wong GW. (2013) C1q/TNF-related protein-11 (CTRP11), a novel adipose stromal-derived regulator of adipogenesis. J Biol Chem. 288:10214-10229.
Byerly MS, Salayta MA, Kwon K, Swanson R, Peterson JM, Wei Z, Moran TH, Aja S, Blackshaw S, Wong GW. (2013) Estrogen-related Receptor β regulates whole body energy balance and attenuates neuropeptide Y gene expression. Eur. J. Neurosci. 37:1033-1047.
Wei Z, Lei X, Seldin MM, and Wong GW. (2012) Endopeptidase cleavage generates a functionally distinct isoform of C1q/TNF-related protein-12 (CTRP12) with an altered oligomeric state and signaling specificity. J Biol Chem. 287:35804-35814.
Marcus M. Seldin, Wong GW. (2012) Regulation of tissue crosstalk by skeletal muscle-derived myonectin and other myokines. Adipocyte. 1:4, 200-202.
Guang TC, Saharabuddhe NA, Kim MS, Getnet D, Yang Y, Peterson JM, Ghosh B, Chaerkady R, Leach SD, Marchionni L, Wong GW, Pandey A. (2012) Regulation of Lipid Metabolism By Dicer Revealed Through SILAC Mice. J. Proteome Res. 11:2193-2205.
Seldin MM, Peterson JM, Byerly MS, Wei Z and Wong GW. (2012) Myonectin (CTRP15), a novel myokine that links skeletal muscle to systemic lipid homeostasis. J Biol Chem. 287:11968-11980.
Wei Z, Peterson JM, Lei X, Cebotaru L, Wolfgang MJ, Baldeviano GC, and Wong GW. (2012) CTRP12, a novel adipokine that improves insulin sensitivity and glycemic control in mouse models of obesity and diabetes. J Biol Chem. 287:10301-10315.
Peterson JM, Aja S, Wei Z and Wong GW. (2012) CTRP1 protein enhances fatty acid oxidation via AMP-activated protein kinase (AMPK) activation and acetyl-CoA carboxylase (ACC) inhibition. J Biol Chem. 287:1576-1587.
Gao X, Lowry P, Zhou X, Depry C, Wei Z, Wong GW, and Zhang J. (2011) PI3K/Akt signaling requires spatial compartmentalization in plasma membrane microdomains. Proc Natl Acad Sci U S A. 108:14509-14
Wei Z, Peterson JM, and Wong GW. (2011) Metabolic regulation by CTRP13: Activation of AMP-activated protein kinase and suppression of lipid-induced JNK signaling pathway. J Biol Chem. 286: 15652-15665.
Peterson JM, Wei Z, Wong GW. (2010) CTRP3, a novel adipokine that regulates hepatic glucose output. J Biol Chem. 285: 39691-39701.
Zhong J, Krawczyk SA, Chaerkady R, Huang H, Goel R, Bader JS., Wong GW., Corkey BE and Pandey A. (2010) Temporal profiling of the secretome during adipogenesis in humans. J. Proteome Res. 9:5228-38.
Deans MR, Peterson JM, and Wong GW. (2010) Mammalian Otolin: A multimeric glycoprotein specific to the inner ear that interacts with otoconial matrix protein otoconin-90 and cerebellin-1. PLoS One. 15;5(9).
Wong GW, Krawczyk SA, Kitidis C, Ge G, Hug C, Spooner E, Gimeno R, and Lodish HF. (2009) Identification and functional characterization of CTRP9, a novel secreted glycoprotein from adipose tissue, that reduces serum glucose in obese mice and forms heterotrimers with adiponectin. FASEB J. 23:241-58.
Wong GW, Krawczyk SA, Kitidis C, Gimeno R, Revett T, and Lodish HF. (2008) Molecular, biochemical, and functional characterization of C1q/TNF family members: adipose tissue-selective expression patterns, regulation by PPAR-γ agonist, Cys-mediated oligomerizations, combinatorial associations, and metabolic function. Biochemical J. 416:161-77.
Wong GW, Wang J, Hug C, Tsao T-S, and Lodish HF. (2004) A family of Acrp30/adiponectin structural and functional paralogs. Proc Natl Acad Sci U S A. 101:10302-10307.