Guang William Wong
|Link to Lab Homepage|
Center for Metabolism and Obesity Research
|Mailing Address||855 N. Wolfe Street|
Baltimore, MD 21205
Mechanisms governing metabolic homeostasis; function of adipose-and skeletal muscle-derived hormones; mechanisms of insulin resistance and type 2 Diabetes
Our lab seeks to understand mechanisms employ by cells and tissues to maintain metabolic homeostasis. We are broadly interested in addressing how adipose- and skeletal muscle-derived hormones (adipokines and myokines), discovered in our lab, regulate tissue crosstalk and signaling pathways to control energy metabolism. Transgenic and knockout mouse models, as well as cell culture systems, are used to address the roles of CTRP family of hormones in physiological and disease states. We also aim to identify the receptors that mediate the biological functions of CTRPs.
Peterson JM, Aja S, Wei Z and Wong GW
. (2012) CTRP1 protein enhances fatty acid oxidation via AMP-activated protein kinase (AMPK) activation and acetyl-CoA carboxylase (ACC) inhibition. J Biol Chem. 287:1576-1587.PubMed Abstract
Wei Z, Peterson JM, Lei X, Cebotaru L, Wolfgang MJ, Baldeviano GC, and Wong GW
. (2012) CTRP12, a novel adipokine that improves insulin sensitivity and glycemic control in mouse models of obesity and diabetes. J Biol Chem. 287:10301-10315.PubMed Abstract
Seldin MM, Peterson JM, Byerly MS, Wei Z and Wong GW
. (2012) Myonectin (CTRP15), a novel myokine that links skeletal muscle to systemic lipid homeostasis. J Biol Chem. 287:11968-11980.PubMed Abstract
Huang TC, Saharabuddhe NA, Kim MS, Getnet D, Yang Y, Peterson JM, Ghosh B, Chaerkady R, Leach SD, Marchionni L, Wong GW
, Pandey A. (2012) Regulation of Lipid Metabolism By Dicer Revealed Through SILAC Mice. J. Proteome Res. 11:2193-2205.PubMed Abstract
Marcus M. Seldin, Wong GW. (2012) Regulation of tissue crosstalk by skeletal muscle-derived myonectin and other myokines. Adipocyte. 1:4, 1-3.
Wei Z, Lei X, Seldin MM, Jia H, and Wong GW
. (2012) Endopeptidase cleavage generates a functionally distinct isoform of CTRP12 with an altered oligomeric state and signaling specificity. J Biol Chem.PubMed Abstract
Wei Z, Peterson JM, and Wong GW
. (2011) Metabolic regulation by CTRP13: Activation of AMP-activated protein kinase and suppression of lipid-induced JNK signaling pathway. J Biol Chem. 286: 15652-15665.PubMed Abstract
Gao X, Lowry P, Zhou X, Depry C, Wei Z, Wong GW
, and Zhang J. (2011) PI3K/Akt signaling requires spatial compartmentalization in plasma membrane microdomains. Proc Natl Acad Sci U S A. 108:14509-14.PubMed Abstract
Zhong J, Krawczyk SA, Chaerkady R, Huang H, Goel R, Bader JS., Wong GW
., Corkey BE and Pandey A. (2010) Temporal profiling of the secretome during adipogenesis in humans. J. Proteome Res. 9:5228-38.PubMed Abstract
Peterson JM, Wei Z, Wong GW. (2010) CTRP3, a novel adipokine that regulates hepatic glucose output. J Biol Chem. 285: 39691-39701.
, Krawczyk SA, Kitidis C, Ge G, Hug C, Spooner E, Gimeno R, and Lodish HF. (2009) Identification and functional characterization of CTRP9, a novel secreted glycoprotein from adipose tissue, that reduces serum glucose in obese mice and forms heterotrimers with adiponectin. FASEB J. 23:241-58.
Wong GW, Krawczyk SA, Kitidis C, Gimeno R, Revett T, and Lodish HF. (2008) Molecular, biochemical, and functional characterization of C1q/TNF family members: adipose tissue-selective expression patterns, regulation by PPAR-γ agonist, Cys-mediated oligomerizations, combinatorial associations, and metabolic function. Biochemical J. 416:161-77.
Wong GW, Wang J, Hug C, Tsao T-S, and Lodish HF. (2004) A family of Acrp30/adiponectin structural and functional paralogs. Proc Natl Acad Sci USA. 101:10302-10307.